This site has been developed for patients who have been prescribed Simponi (golimumab). Here are some things you might like to know about your medication:
For Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA), Non-Radiographic Axial Spondyloarthritis (nr-axSpA) and Ankylosing Spondylitis (AS): same day every month
For Ulcerative Colitis (UC): once every 4 weeks after induction doses at week 0 and 2
The SmartJect pen was created in collaboration with patients and nurses
Simponi (golimumab) is for people with Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA), Non-Radiographic Axial Spondyloarthritis (nr-axSpA), Ankylosing Spondylitis (AS) and Ulcerative Colitis (UC). It is prescribed when people have had limited success with painkillers, disease-modifying drugs and other medicines.
Your immune system naturally produces a protein called tumour necrosis factor alpha (TNF-alpha). When your body produces too much TNF-alpha this can lead to:
Simponi is an anti-TNF, this means that it works by blocking TNF-alpha:
Click on one of the boxes to learn more:
In RA the body produces too muh TNF-alpha, making your body mistakenly start attacking the tissue lining your joints. This causes inflammation, making your joints painful and swollen, and may lead to joint damage in the long term.
Psoriasis is a condition that causes areas of your skin to become red and swollen.
When people with psoriasis produce too much TNF-alpha, you can develop PsA. This causes your body to mistakenly start attacking the tissue lining your joints, making them painful and swollen.
PsA most commonly affects the fingers, toes, knees and elbows – but can occur in any joint. Dactylitis is the name used to describe when a finger or toe becomes swollen, caused by joints and tendons being inflamed at the same time.
Axial SpA may be diagnosed as either AS (Ankylosing Spondylitis), or nr-axSpA (Non-Radiographic Axial Spondyloarthritis) if joint damage is not present on X-rays or does not meet certain criteria.
In AS and nr-axSpA the body produces too much TNF-alpha, making your body mistakenly start attacking the area where your ligaments attach to your spine. This causes inflammation and can lead to the vertebrae in your lower back fusing, causing pain and stiffness.
As well as your back, the hip, ankle, elbow, heel or shoulder joints can also be affected.
Ulcerative Colitis is a type of inflammatory bowel disease. It is a long-term condition, but you will have periods when your symptoms are reduced (remission) and flares, when they will temporarily get worse. In people with UC, your body produces too much TNF-alpha, causing your immune system to mistakenly start attacking healthy tissue in your colon.
The exact cause of UC is unknown, but it is thought to be influenced by:
For further information about Simponi (golimumab) please contact our Medical Information Department at:
Medical Information Department
Merck Sharp & Dohme Ltd.
Tel: 01992 467272
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