Are allergic to golimumab or another ingredient in Simponi
Have tuberculosis (TB) or another severe infection
Have moderate or severe heart failure
Are pregnant or breast-feeding
Before you take Simponi, you must tell your doctor if you:
Recently had, or are due, a vaccine
Are going to have an operation, including dental procedures
Are planning to get pregnant
Have severe asthma, COPD (a type of lung disease) or are a heavy smoker
Have a congestive heart condition
Have travelled to areas where fungal, TB or other infections are common
Are allergic to sugars (including sorbitol and fructose) or latex
Have Hepititis B, or carry the Hepatitis B virus
Have ever been diagnosed with any form of cancer
Have or get any symptoms of infection
Have or develop any heart problems, such as mild heart failure
Have or develop problems that affects your nervous system
Develop symptoms of lupus
Have a fever that does not go away, bruise or bleed easily
Talk to your doctor
Before you take Simponi, your doctor will test you for TB. You should also let your doctor know immediately if you notice any of the following during or after your treatment:
Signs of infection (including TB)
A persistent cough
Shortness of breath
Burning sensation when passing urine
Signs of allergic reaction
Swelling of the face, lips, mouth and throat
Swelling of the hand, feet or ankles
Difficulty swallowing or breathing
Skin rash, including hives
Signs of liver problems
Yellowing of the skin or eyes
Dark brown urine
Right-sided abdominal pain
Nausea and vomiting
Signs of heart failure
Shortness of breath
Swelling of the feet
If you experience any side effects (including any not listed above), talk to your healthcare professional. You can report side effects via the Yellow Card Scheme at https://yellowcard.mhra.gov.uk or search for MHRA Yellow Card in the Google Play or Apple App Store – this helps to provide more information on the safety of this medicine.
If you notice anything unusual, contact your healthcare professional, especially if:
The injection site continues to bleed
The injection is very painful
A rash develops around the injection site
You get a fever or develop signs of an allergic reaction
Simponi is a prescription-only medicine and must be used under medical supervision.
Reporting side effects
If you experience any side effects talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in the package leaflet. You can also report side effects directly via the Yellow Card Scheme at https://yellowcard.mhra.gov.uk or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.
Adverse events should be reported. Reporting forms and information can be found at https://yellowcard.mhra.gov.uk or search for MHRA Yellow Card in the Google Play or Apple App Store. Adverse events should also be reported to Merck Sharp & Dohme Limited (tel: 01992 467272).
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Kanai T et al. Korean J Intern Med 2014; 29(4): 409-15
Olendzki BC et al. Nutr J 2014; 13(5): 1-7.
Brown AC et al. Expert Rev. Gastroenterol. Hepatol 2011; 5(3): 411-25
Pituch-Zdanowksa A et al. Prz Gastroenterol 2015; 10(3): 135-41.
Oliviero F et al. Swiss Med Wkly 2015; 145: w14190.
Clinton CM et al. Arthritis 2015; 2015: Article ID 708152.
Narula N, Fedorak RN. Can J Gastroenterol 2008; 22 (5): 497-504
Bilski J et al. BioMed Res Int 2014; Volume 2014 (Article ID 429031): 1-14.